After a feeling-out period in the early going, the visitors found the first chances. Javier Aquino and new signing Ismael Sosa both had some opportunities, with Sosa forcing a good save out of Agustín Marchesín with a diagonal shot.
Santos Laguna responded through Fredy Hinestroza, who came within inches of scoring a beautiful volleyed goal but was denied by the post. The Laguneros were denied by the woodwork again in the second half, when Jonathan Rodríguez also hit the post.
In the 50th minute, the Laguneros had a penalty shout denied after referee Jorge Antonio Pérez declined to call an apparent handball on Juninho in the box.
In the 64th, the universitarios mounted a counterattack through Israel Jiménez, who tried to chip Marchesín, but the goalkeeper did just enough to send the ball out for a corner kick.
Tigres then found an opportunity from a set piece, with Juninho’s free kick hitting the woodwork. Then, in the 80th minute, Sosa thought he had given Tigres the lead, only for his would-be goal to be controversially disallowed for offside.
Santos, too, had an opportunity for a late winner, but once again the goalposts denied them, with Jesús Molina’s header crashing against the crossbar.
With the 0-0 draw, Santos and Tigres both reach one point.
Santos: Agustín Marchesín, Néstor Araujo, Jorge Flores, Carlos Izquierdoz, José Javier Abella, Jesús Molina, Diego de Buen (Ulises Dávila 77′), Bryan Rabello (Walter Sandoval 66′), Emiliano Armenteros, Jonathan Rodríguez, Fredy Hinestroza (Martín Bravo 77′).
Tigres: Nahuel Guzmán, Israel Jiménez, Juninho, Hugo Ayala, Jorge Torres Nilo, Jesús Dueñas, Lucas Zelarayán (Fernando Fernández 65′), Damián Álvarez (José Francisco Torres 88′), Manuel Viniegra, Javier Aquino (Luis Quiñones 66′), Ismael Sosa.