América had the first chance of the game in the 6th minute, when Osvaldo Martínez sent his free kick attempt crashing against the woodwork. After that opportunity, Tigres slowly began to control possession, although they were lacking the final touch to trouble Hugo González.
Then, in the 37th minute, Javier Aquino scored a golazo, sending the ball into the upper corner to give the visitors the 0-1 lead.
Then, just before halftime, Renato Ibarra was given a straight red card for a foul on Juninho, leaving Ámerica down a goal and down a man with 45 minutes left to play.
In the second half, Tigres took advantage of their extra man to continue to control the game. In the 59th minute, the universitarios added to their lead through André-Pierre Gignac, who shot past the onrushing González to make it 0-2 after receiving the ball in the box.
Ismael Sosa then put the cherry on top of the win with his stoppage-time goal to give Tigres the 0-3 lead.
With the 0-3 win, Tigres reach five points while América remains on six.
América: Hugo González, Paul Aguilar, Bruno Valdez, Pablo Aguilar, Osmar Mares, Rubens Sambueza, Osvaldo Martínez, José Daniel Guerrero (Jesús Moreno 84′), Renato Ibarra, Silvio Romero, Carlos Quintero (William da Silva 60′).
Tigres: Nahuel Guzmán, Israel Jiménez, Hugo Ayala, Juninho, Alberto Acosta (Manuel Viniegra 76′), Lucas Zelarayán (Jürgen Damm 60′), José Francisco Torres, Ismael Sosa, Guido Pizarro, Javier Aquino (Luis Quiñones 84′), André-Pierre Gignac.