This reformatted cup competition saw the top two teams in each group advance to this round, when in previous years only eight teams advanced and the knockout stage started with the quarterfinals.
The eight group winners and eight runners-up were seeded based on the total points accumulated in the group stage and then paired up accordingly. Eleven teams from Liga MX and five from Ascenso MX will now square off for a spot in the quarterfinals.
The round of sixteen schedule and match-ups are as follows. All times Eastern, home team listed first.
Tuesday, September 27
Puebla (3) vs Leones Negros (14) – 8:00 PM
Jaguares de Chiapas (8) vs Atlante (9) – 8:00 PM
Monarcas Morelia (5) vs Chivas de Guadalajara (12) – 10:00 PM
Cruz Azul (2) vs Mineros de Zacatecas (15) – 10:00 PM
Wednesday, September 28
Toluca (6) vs León (11) – 8:00 PM
Querétaro (7) vs Lobos BUAP (10) – 8:00 PM
América (1) vs Veracruz (16) – 10:00 PM
FC Juárez (4) vs Alebrijes de Oaxaca (13) – 10:00 PM