The Águilas came out looking for a statement win after their midweek Copa MX loss to rivals Chivas, and they looked like the better team from the opening whistle. They earned a penalty very early on after Néstor Araujo fouled Renato Ibarra, and Silvio Romero converted the spot kick to make it 1-0 in the 8th minute.
But the early goal seemed to wake up Santos Laguna, who began to press forward themselves. In the 32nd minute they found the equalizer as Djaniny Tavares jumped highest to head home a free kick.
However, the match was level for just eight minutes before América retook the lead. In the 40th minute, Ibarra started a run from within his own half and took the ball all the way to the endline. Michael Arroyo was there at the far post to knock in the cross and make it 2-1.
Then, in the second half, Rubens Sambueza ran on to a pass at the top of the box and followed up his own rebound to make it 3-1 and put the game definitively out of reach in the 63rd minute.
With the 3-1 win, América reaches 26 points while Santos remains on 10.
América: Moisés Muñoz, Edson Álvarez, Paolo Goltz, Pablo Aguilar, Osmar Mares, José Daniel Guerrero, Osvaldo Martínez (William da Silva 20′), Renato Ibarra, Michael Arroyo, Rubens Sambueza, Silvio Romero (Oribe Peralta 66′).
Santos: Agustín Marchesín, José Javier Abella, Carlos Izquierdoz, Néstor Araujo, Gerardo Arteaga, Jesús Molina, Ulises Rivas (Freddy Hinestroza 73′), Bryan Rabello (Mauricio Cuero 66′), Walter Sandoval, Jonathan Rodríguez (Martín Bravo 62′), Djaniny Tavares.