The semifinals are a total goals, aggregate score series; away goals are tiebreakers. Should both the aggregate and the away goals be tied at the end of the second leg, the higher seed will advance.
All times Eastern, home team listed first.
Liguilla – Playoffs – Semifinal First Legs
Wednesday, November 30
León (8) vs Tigres UANL (3) – 9:36 PM – Univision Deportes / FuboTV
Thursday, December 1
Necaxa (7) vs América (5) – 10:00 PM – Univision Deportes / FuboTV