The round of sixteen is single-elimination, with the winner of each game advancing to the quarterfinals. Should a game be tied at the end of regulation, it will proceed directly to a penalty shootout (no extra time will be played).
All times Eastern, home team listed first.
Copa MX – Round of 16
Tuesday, March 7
Querétaro vs FC Juárez – 8:00 PM
Jaguares de Chiapas vs Puebla – 8:00 PM – Univision Deportes / FuboTV
Monterrey vs Mineros de Zacatecas – 10:00 PM
Chivas de Guadalajara vs Correcaminos – 10:00 PM – Univision Deportes / FuboTV
Wednesday, March 8
Toluca vs Monarcas Morelia – 8:00 PM
León vs Cruz Azul – 8:00 PM – Univision Deportes / FuboTV
Tijuana vs América – 10:00 PM – Univision Deportes / FuboTV
Necaxa vs Santos Laguna – 10:00 PM