This is the first edition of the new tournament format, which has done away with the group stage and will be a straight knockout format throughout the competition. The changes also mean the Champions League will be held entirely in the same calendar year, rather than the split format that had been used in the past.
The Round of Sixteen will begin in February, and it will be a home-and-away, two-legged aggregate goals series. Away goals are tiebreakers.
Mexico has four entrants: Tigres UANL (Apertura 2016 champions), Chivas de Guadalajara (Clausura 2017 champions), América (Apertura 2016 runners-up), and Tijuana (non-finalist with best regular season Clausura 2017 record). The Xolos were given a CCL berth as Tigres UANL, who had already qualified for the continental competition with their Apertura 2016 victory, were also the runners-up in the Clausura 2017 season.
The complete draw is as follows:
Chivas de Guadalajara (MEX) vs Cibao FC (DOM)
Seattle Sounders (USA) vs Santa Tecla (SLV)
New York Red Bulls (USA) vs CD Olimpia (HON)
Tijuana (MEX) vs FC Motagua (HON)
Tigres UANL (MEX) vs Herediano (CRC)
Toronto FC (CAN) vs Colorado Rapids (USA)
FC Dallas (USA) vs Tauro FC (PAN)
América (MEX) vs Saprissa (CRC)