The quarterfinals are single elimination games held at the home of the higher seed. If a game is tied at the end of regulation, the winner will be decided by penalty kicks (no extra time will be played).
All times Eastern.
Copa MX Quarterfinals
Tuesday, March 13
Zacatepec vs León – 9:06 PM
Santos Laguna vs Querétaro – 11:15 PM
Wednesday, March 14
Cafetaleros vs Toluca – 9:00 PM
Pumas UNAM vs Necaxa – 11:15 PM