Chivas was held to a 0-0 draw in their second leg against the New York Red Bulls, but that result was still enough to advance El Rebaño with a 1-0 aggregate victory.
Toronto FC went to the Estadio Azteca and drew 1-1 with América, which saw them advance 4-2 on aggregate.
Chivas and Toronto will now face off to determine the regional champion. The first leg will be held at Toronto between April 17-19, with the return leg in Guadalajara between April 24-26.
The exact dates and times of the matches will be announced shortly.