The Round of Sixteen consists of single-elimination games held at the home of the higher seed. Should the teams be tied at the end of the regulation 90 minutes, advancement will be decided by a penalty shootout; no extra time will be played.
All times Eastern, home team listed first.
Copa MX Round of Sixteen
Tuesday, September 25
Necaxa vs León – 8:00 PM – Univision Deportes / FuboTV
Pachuca vs Cafetaleros – 8:00 PM – ESPN Deportes
América vs FC Juárez – 10:00 PM – Univision Deportes / FuboTV
Tijuana vs Cruz Azul – 10:00 PM – Fox Deportes
Wednesday, September 26
Tigres UANL vs Puebla – 8:00 PM
Querétaro vs Dorados de Sinaloa – 8:00 PM – Univision Deportes / FuboTV
Chivas de Guadalajara vs Pumas UNAM – 10:00 PM – Univision Deportes / FuboTV
Monterrey vs Zacatepec – 10:00 PM – Fox Deportes