The semifinals are a total goals, aggregate score series; away goals are tiebreakers. Should the aggregate and away goals both be tied at the end of the second leg, the higher seed will advance.
All times Eastern, home team listed first.
Playoffs – Liguilla – Semifinal First Legs
Wednesday, May 15
Monterrey (3) vs Tigres UANL (2) – 10:06 PM – Fox Deportes
Thursday, May 16
América (5) vs León (1) – 9:30 PM – Univision Deportes / FuboTV