The hosts had their chances; Unai Bilbao came within inches of giving San Luis the lead with his header that crashed against the crossbar, and Ian González had a pair of chances as well, only for Alfredo Saldívar to make the necessary saves.
Pumas, on the other hand, was quiet in the first half, with their first notable chance not coming until the 42nd minute when David Cabrera tried his luck from outside the box – but the shot went wide.
In the second half, though, the universitatios looked more dangerous. Carlos González had an early chance but was stopped by goalkeeper Carlos Rodríguez. Then, in the 57th minute, it seemed that they might get a penalty kick, but after VAR review it was waved off.
San Luis then saw captain Pedro Álvarez carried off the field after he fell badly following a foul; he was subbed off for Mario de Luna in the 69th minute.
It took until the 79th minute for Pumas to break the deadlock. Carlos González brought a cross down with his chest and then sent his shot past Rodríguez to make it 0-1 for the visitors.
San Luis looked for a response, but instead Pumas added an insurance goal. In the 88th minute, Luis Quintana assured the victory when he headed home a corner kick to make it 0-2.
With the 0-2 win, Pumas reach three points while San Luis still has zero.