The quarterfinals are two-legged, aggregate-goal series; away goals are tiebreakers. If both the aggregate and the away goals are tied at the end of the second leg, the higher seed will advance.
The first legs are hosted by the lower seeds and will be played on Wednesday and Thursday.
All times Eastern.
Playoffs – Quarterfinal First Legs
Thursday, November 28
Monterrey (8) vs Santos Laguna (1) – 8:06 PM – Fox Deportes / FS2
América (6) vs Tigres UANL (3) – 10:05 PM – TuDN / FuboTV