The round of sixteen is a total goals, aggregate score series; away goals are not tiebreakers. Should the aggregate be tied at the end of the second leg, the winner will be determined by penalty kicks – no extra time will be played.
All times Eastern, home team listed first.
Copa MX – Round of 16 First Legs
Tuesday, January 21
Querétaro vs FC Juárez – 8:00 PM – TuDN / FuboTV
Venados vs Pachuca – 8:00 PM – ESPN Deportes
Chivas de Guadalajara vs Dorados de Sinloa – 10:00 PM
Atlético San Luis vs Tijuana – 10:00
Wednesday, January 22
Celaya vs Monterrey – 8:00 PM – TuDN / FuboTV
Cafetaleros vs Monarcas Morelia – 8:00 PM – ESPN Deportes
Atlas vs Toluca – 10:00 PM – TuDN / FuboTV
Santos Laguna vs Pumas UNAM – 10:00 PM – Fox Deportes